Sinclair Method Studies
Published on: 11/06/2025
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
Gradual Alcohol Reduction: A Smarter, Science-Backed Way to Take Control
Published on: 16/04/2025
Let’s face it—quitting alcohol overnight can be intimidating, and for many, it’s simply not sustainable. That’s where gradual alcohol reduction offers a more realistic and compassionate approach. Rather than forcing complete abstinence from the start, this method gives us time to adjust our relationship with alcohol in a way that feels manageable and lasting.
The Sinclair Method (TSM)
The Sinclair Method: A Revolutionary Approach to Alcohol Harm Reduction
Published on: 03/04/2025
The Sinclair Method (TSM) is an evidence-based treatment for Alcohol Use Disorder (AUD) that diverges from traditional abstinence-focused approaches. Developed by Dr. John David Sinclair, TSM employs the opioid antagonist naltrexone to disrupt the brain's association between alcohol consumption and pleasurable sensations. This process, known as pharmacological extinction, gradually diminishes the desire to drink.
The Sinclair Method (TSM)
